Sepsis prevents the development of experimental type 1 diabetes.

ABSTRACT:

Introduction

While both sepsis and autoimmunity are characterized by dysregulated immune responses, their mutual influence remains only partially understood.

Methods

In this study, we investigated how sepsis affects the development of type 1 diabetes (T1D), an autoimmune disease characterized by the destruction of pancreatic β-cells. Specifically, we examined the impact of polymicrobial sepsis on the progression of T1D induced by multiple low doses of streptozotocin (MLDS). C57BL/6 mice were subjected to cecal ligation and puncture (CLP) to induce sepsis, and T1D was subsequently induced using the MLDS protocol after the mice had fully recovered from the acute phase of sepsis.

Results and discussion

Although CLP triggered transient hypoglycemia, it did not impair the

SUBMITTER: Stegnjaic G 

PROVIDER: S-EPMC12546358 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature