Effect of ranitidine hydrochloride on water activity in ternary aqueous solutions containing drug and ionic liquid based on vapor liquid equilibria at 298.15 K.

ABSTRACT: Vapor-liquid equilibrium (VLE) studies were carried out to investigate the influence of ranitidine hydrochloride (Rani-HCl) on the thermodynamic behavior of aqueous solutions containing various pharmaceutical compounds and ionic liquids (ILs). The drugs examined alongside Rani-HCl included diphenhydramine hydrochloride (DPH-HCl), guaifenesin (GFN), and naproxen sodium (NS), while the selected ILs were 1-butyl-3-methylimidazolium chloride ([BMIm]Cl), 1-butyl-3-methylimidazolium bromide ([BMIm]Br), and 1-butyl-1-methylpyrrolidinium trifluoromethanesulfonate ([BMP][TfO]). VLE measurements were performed using the isopiestic method at a constant temperature of 298.15 K. To analyze the data, several local composition models-TNRF-mNRTL, NRTL, NRF-NRTL, mNRTL, and Wilson-were employed to compute

SUBMITTER: Majdan-Cegincara R 

PROVIDER: S-EPMC12546613 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature