Identification of biomarkers associated with glycolysis and lactation in sarcopenia.

ABSTRACT: Sarcopenia, characterized by the loss of muscle mass, is a primary contributor to frailty among the elderly population. In recent years, several studies have highlighted the relationship between sarcopenia and glycolysis as well as lactylation; however, the underlying mechanisms remain unclear. This study aims to investigate the mechanisms linking sarcopenia with glycolysis and lactylation through bioinformatics approaches, thereby providing insights for potential therapeutic strategies in managing related diseases. We obtained the sarcopenia dataset from the Gene Expression Omnibus (GEO) database, The data sets were performed differential analysis and weighted correlation network analysis (WGCNA) analysis. Glycolysis and lactylation-related genes were obtained using MSigDB database, and i

SUBMITTER: Luo X 

PROVIDER: S-EPMC12546629 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature