Kidney Function Trajectories With Mechanical Circulatory Support.

ABSTRACT:

Introduction

Adverse long-term kidney outcomes with left ventricular assist devices (LVADs) are common but little understood. Creatinine-based estimated glomerular filtration rate (eGFR) is used clinically in this setting; however, it is of uncertain validity and tends to change nonlinearly after LVAD implantation with an early peak followed by decline. We investigated nonlinear eGFR trajectories over 90 days following LVAD implantation and the relationships with patient factors and outcomes.

Methods

We used 2 complementary cohorts of LVAD recipients, a single-center cohort (n = 190) and a US national cohort (n = 10794). Segmented linear regression with 2 segments was compared to other trajectory models. Relationships of trajectory parameters with patient facto

SUBMITTER: Walther CP 

PROVIDER: S-EPMC12546638 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature