Natural variation in the GhTTL promoter modulates cotton fiber elongation through the GhTALE-GhTTL-GhBIN2 module.

ABSTRACT: In cotton, fiber length is a key determinant of industrial utility and is one of the most important agricultural traits shaped during domestication. However, the genetic determinants and molecular mechanisms underlying natural variation in fiber length remain poorly characterized. In this study, we identified GhTTL as a critical positive regulator of fiber elongation through genome-wide association study (GWAS). Natural polymorphisms in the cis-regulatory element of the GhTTL promoter region were found to significantly affect its binding affinity for the transcription factor GhTALE, thereby modulating GhTTL expression across diverse cotton populations. Mechanistic investigations revealed that GhTTL interacts with GhBIN2, a central negative regulator of the brassinosteroid (BR) signaling pa

SUBMITTER: Liu L 

PROVIDER: S-EPMC12546657 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature