Association between serum fatty acids and microcirculation in kidney transplant recipients.

ABSTRACT: Chronic kidney disease (CKD) is associated with an increased cardiovascular risk, including microvascular complications. Previous studies have shown alterations in the fatty acid profile in kidney transplant (KT) recipients, which included deficiencies in polyunsaturated fatty acids (PUFA). The goal of this study was to determine the associations between the fatty acid profile and microvascular parameters in KT patients. The fatty acids 22:4n-6 and 20:4n-3 negatively correlated with the wall-to-lumen ratio (WLR), with respective R-values being - 0.39 (p = 0.017) and - 0.405 (p = 0.013), suggesting their potential protective effect on microcirculation, despite their levels being decreased after KT. Additionally, 18:2n-6, a precursor of pro-inflammatory oxylipins, showed a positive correlati

SUBMITTER: Dabrowska E 

PROVIDER: S-EPMC12546703 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature