Global DNA methylation signatures associated with chemoresistance and poor prognosis of high grade serous ovarian cancer.

ABSTRACT: Ovarian cancer (OVCA) is third most lethal gynecologic cancers and acquired chemoresistance is the key link in the high mortality rate of OVCA patients. Currently, there are no reliable methods to predict chemoresistance in OVCA. In our study, we identify genes, pathways and networks altered by DNA methylation in high-grade serous ovarian carcinoma (HGSC) cells that are associated with chemoresistance and prognosis of HGSC patients. We performed methylome-wide profiling using Illumina Infinium MethylationEPIC BeadChip (HM850K) methylation array on a set of HGSC chemoresistant and chemosensitive cell lines. Differentially Methylated CpG Probes (DMPs) were identified between the resistant and sensitive groups in HGSC. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) over

SUBMITTER: Manzoor HB 

PROVIDER: S-EPMC12546721 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature