Efficacy of Calcineurin Inhibition in Children With Steroid-Resistant Nephrotic Syndrome.

ABSTRACT:

Introduction

We aimed to provide evidence for the efficacy of calcineurin inhibitor (CNI) treatment in children with steroid-resistant nephrotic syndrome (SRNS).

Methods

In 278 SRNS children receiving first-line CNI treatment, cumulative remission and kidney failure incidence were estimated using competing risk analysis. Kaplan-Meier and Cox regression analyses were performed to analyze kidney survival, identify predictors of CNI responsiveness and estimate the cumulative incidence of breakthrough proteinuria episodes on or off CNI treatment. The impact of CNI dosage and trough levels on proteinuria was assessed using multivariable linear-mixed effects modeling.

Results

Within 6 months of CNI administration, proteinuria was reduced by 84% (interquartile range: 80%-87%

SUBMITTER: Trautmann A 

PROVIDER: S-EPMC12546756 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature