Identifying gene expression signatures of oncolytic virus response in patient-derived pancreatic ductal adenocarcinoma organoids.

ABSTRACT: Pancreatic ductal adenocarcinoma is among the deadliest cancers, with a poor prognosis. Viro-immunotherapy using oncolytic viruses represents a promising treatment. However, pancreatic ductal adenocarcinoma from different patients responds variably to these therapies, highlighting the need for predictive biomarkers. This study aimed to identify gene expression profiles that predict responses to oncolytic viruses. Patient-derived organoids (PDOs) from ten pancreatic ductal adenocarcinoma patients were evaluated for sensitivity to Newcastle disease virus (NDV), reovirus (RV), measles virus, and a gorilla-derived adenovirus. The sensitivity data revealed heterogeneous responses, with nine of ten PDOs being sensitive to at least one virus. The sensitivity of PDOs was correlated with their base

SUBMITTER: Huberts M 

PROVIDER: S-EPMC12546772 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature