Recent Abdominal Surgery as a Risk Factor for Unfavorable Immune-Mediated Colitis Outcomes.

ABSTRACT:

Background and aims

Risk factors for immune checkpoint inhibitor (ICI) therapy enterocolitis (IMC) have not been greatly explored. Abdominal surgery can reduce bacterial diversity, increase the presence of pathogenic bacteria, and lead to inflammatory changes. This retrospective analysis seeks to determine if a history of recent abdominal surgery in patients who receive ICI therapy affects the severity and duration of enterocolitis.

Methods

We retrospectively reviewed patients with history of abdominal surgeries, who received ICI for cancers and then developed IMC. Clinical profiles, oncology variables, and colitis-related characteristics were reported.

Results

Seven hundred sixty-five patients met the inclusion criteria. Patients median age was 64 years, were predomi

SUBMITTER: Ahuja R 

PROVIDER: S-EPMC12546776 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature