Elevated LL-37/FPR2 Axis and its Regulatory Role for Gingival Fibroblasts in Periodontitis.

ABSTRACT:

Introduction and aims

LL-37, an antimicrobial peptide with dual pro-/anti-inflammatory roles, has been implicated in the pathogenesis of periodontitis, yet its specific action through its receptor Formyl peptide receptor 2 (FPR2) remains unclear. This study aimed to elucidate the expression profile of the LL-37/FPR2 axis in periodontitis and its regulatory effects on gingival fibroblasts (GFs).

Methods

Fifty-seven periodontitis patients and fifty-seven healthy controls were included to assess the levels of LL-37 and FPR2 in gingival tissues, gingival crevicular fluid and GFs, as well as to assess their correlation with disease progression. Primary human GFs were isolated and subsequently stimulated with Porphyromonas gingivalis lipopolysaccharide alongside varying concentrat

SUBMITTER: Lin T 

PROVIDER: S-EPMC12546779 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature