Targeting proBDNF in neutrophil subsets: Sepsis biomarker discovery and insights into mitochondrial hyperactivation.

ABSTRACT: Sepsis, characterized by dysregulated immune responses, necessitates biomarkers and therapies. We conducted a prospective multicentric observational study involving sepsis patients and control groups. The proportions and brain-derived neurotrophic factor precursor (proBDNF) expression of blood neutrophil subsets were detected, and their clinical value was evaluated via correlation analysis and receiver operating characteristic curve analysis. ProBDNF was significantly upregulated in immature neutrophils (CD16^int Neu) in sepsis patients and slightly elevated in mature Neu (CD16^hi Neu). ProBDNF expression in CD16^int Neu showed promising diagnostic value for sepsis, with a specific positive correlation with disease severity, prognosis, and organ dysfunction. C

SUBMITTER: Li Q 

PROVIDER: S-EPMC12546784 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature