Unravelling pain in Gottingen Minipigs undergoing experimentally induced closed-chest myocardial infarction: a prospective cohort study.

ABSTRACT: The pain associated with experimental myocardial infarction in pigs has never been investigated. We aimed at assessing pain and its correlation with myocardial damage. Twenty-four Göttingen minipigs undergoing closed chest myocardial infarction followed by coronary reperfusion under general balanced anaesthesia were included in the trial. Pain was assessed through mechanical and thermal thresholds, sensitivity to Von Frey filaments and behavioural indicators before (Pre MI), the day after (Post MI) and at the study endpoint (Post MI-endpoint). Over time differences in mechanical thresholds (MT) and thermal thresholds (TT) were assessed using one-sample t-test and their correlations with troponin I/cytokines using logistic regression. In four minipigs at Post MI acute pain requiring analges

SUBMITTER: Petrucci M 

PROVIDER: S-EPMC12546812 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature