Sleep recovery alleviates impaired glucose tolerance induced by sleep fragmentation possibly through gut microbiota in mice.

ABSTRACT: Sleep disturbance is increasingly common and has been linked to adverse metabolic outcomes. This study investigated whether sleep recovery (SR) mitigates the effects of chronic sleep fragmentation (SF) on glucose metabolism, with a focus on gut microbiota and inguinal white adipose tissue (iWAT) transcriptomics. Mice were subjected to 8 weeks of SF followed by SR. After 2 weeks of SR (SF 8w-SR 2w), glucose intolerance persisted, accompanied by significant alterations in gut microbiota composition and iWAT gene expression. Key hub genes (Ncapg, Cenpe, Ttk) and glucose metabolism-related genes (Lnpep, Pten, Apoe, Cebpb, Ido1, Ahsg) were identified. Bacterial genera were significantly altered and associated with glucose metabolism. After 8 weeks of SR (SF 8w-SR 8w), glucose tolerance was rest

SUBMITTER: Zhang J 

PROVIDER: S-EPMC12546819 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature