Comprehensive analysis of aberrant alternative splicing and RNA binding proteins associated with age-related sensorineural hearing loss.

ABSTRACT: The prevalence of RNA binding proteins (RBPs) in regulating alternative splicing (AS) in age-related sensorineural hearing loss (SNHL) is unclear. To address this question, we comprehensively analyzing RNA-seq data from a mouse model to identify deregulated AS events (RASEs) and differentially expressed RNA binding proteins (DERBPs) associated with age-related SNHL, and constructed the networks between these two levels of changes. We have identified 198 and 187 RASEs related to severe and mild symptoms, respectively. Genes harboring these RASEs are significantly enriched in positive regulation of GTPase activity and cytoskeleton organization. We further identified 25 and 14 DERBPs related to severe and mild symptoms, respectively, and constructed the regulatory network between DERBPs and R

SUBMITTER: Yu W 

PROVIDER: S-EPMC12546835 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature