Maternal postpartum sedentary life exacerbates the metabolic impact of moderately fat-rich diet in male mice.

ABSTRACT: Profound social and economic changes in recent generations have led to reduced physical activity and increased calorie intake, leading to a higher incidence of metabolic disease. These effects may propagate across generations, amplifying the impact on descendants. Here we found that limited physical activity of dams brought about increased liver weight and lipid accumulation in the male offspring on a moderate fat calorie western-like diet from weaning to adulthood, while maternal voluntary exercise on running wheels during the postpartum period was sufficient to prevent the development of the phenotype in the otherwise sedentary offspring. Elevated fatty acid (FA) and reduced acylcarnitine levels in the liver of offspring of exercising mothers suggested increased FA flux for oxidation tha

SUBMITTER: Lopez K 

PROVIDER: S-EPMC12546880 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature