Global, regional, and national burden of atrial fibrillation and atrial flutter in the working-age population from 1990 to 2021: A systematic analysis based on 2021 global burden of disease data.

ABSTRACT: Atrial fibrillation and atrial flutter impose a significant global health burden, particularly among individuals aged 30-64 years. This study analyzed data from the Global Burden of Disease 2021 database to estimate disease burden trends from 1990 to 2021. Key metrics included age-standardized incidence, prevalence, mortality, and disability-adjusted life years rates, stratified by age, sex, and Socio-Demographic Index. The methodologies encompassed descriptive analysis, age-period-cohort modeling, decomposition techniques, and Bayesian forecasting. From 1990 to 2021, age-standardized incidence rates increased by an estimated annual percentage change of 0.14, prevalence rates by 0.20, and disability rates by 0.08, while mortality rates declined by 0.16. By 2021, global incidence reached 47

SUBMITTER: Yang C 

PROVIDER: S-EPMC12546894 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature