Complementary immunoregulatory effects of <i>Bifidobacterium longum</i> 1714^TM associated exopolysaccharide and tryptophan metabolism.

ABSTRACT: Specific bifidobacterial strains can reduce aberrant inflammatory responses, but the strain-specific factors that promote regulatory immune responses are not well elucidated. The aims of this study were to assess the effects of Bifidobacterium longum 1714™ on innate inflammatory responses and to identify the strain-associated features that mediate its immunomodulatory effects. B. longum 1714 induced peripheral blood mononuclear cell (PBMC) and monocyte derived dendritic cell (MDDC) cytokine secretion and costimulatory molecule expression in a strain specific manner. B. longum 1714 consumption reduced excessive cytokine responses in LPS-induced, stress-induced and obesity-induced inflammation in murine models. B. longum 1714 produced a branched hexasaccharide rep

SUBMITTER: Groeger D 

PROVIDER: S-EPMC12546897 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature