Effect of sleep apnoea interventions on multiple health outcomes: an umbrella review of meta-analyses of randomised controlled trials.

ABSTRACT:

Background

Obstructive sleep apnoea (OSA) is a prevalent chronic condition that is associated with cardiometabolic and neurocognitive complications. While continuous positive airway pressure (CPAP) remains the first-line therapy, suboptimal adherence limits its effectiveness, highlighting the need to evaluate alternatives such as mandibular advancement devices (MADs), hypoglossal nerve stimulation (HNS), physical activity, different modalities of weight loss management including glucagon-like peptide-1 (GLP-1) agonists and combination therapies.

Methods

We conducted an umbrella review to synthesise high-level evidence from meta-analyses of randomised controlled trials (RCTs) evaluating the efficacy, adherence, and safety of therapies used in patients with OSA. A comprehensiv

SUBMITTER: Figard C 

PROVIDER: S-EPMC12547021 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature