Disease course after pregnancy in women with progressive multiple sclerosis symptoms.

ABSTRACT:

Background

The impact of pregnancy on disease outcomes has not been characterised in women with progressive multiple sclerosis (MS) phenotypes. This study aimed to describe the clinical characteristics and disease course of women who experienced a pregnancy after a diagnosis of primary progressive MS (PPMS) or secondary progressive MS (SPMS).

Methods

This multicentre observational cohort study utilised data from the international MSBase Registry extracted on 2 June 2024. Expanded Disability Status Scale (EDSS) scores of women with progressive MS were assessed up to 10 years postpartum and compared to those of propensity score-matched women with progressive MS without a pregnancy history.

Results

In total, 138 women with 164 pregnancies were included in the study, comp

SUBMITTER: Shipley J 

PROVIDER: S-EPMC12547043 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature