Solid-Liquid Interface Lubricating Hydrogels for Tendon-Bone Healing.

ABSTRACT: A solid-liquid interface lubrication system composed of tissue and synovial fluid ensures the physiological functions of the tendon-bone (TB). However, after the TB tears, stress concentration and friction disrupt the solid-liquid interface lubrication of the TB and disturb its healing. Herein, solid-liquid interface lubrication hydrogels (MnCaP/HS) are constructed by encapsulating ion-coordinated calcium manganese phosphate microgels into covalent/ionic-cross-linked hyaluronic acid/sodium alginate dual networks. Solid lubrication interfaces are thus formed at the damaged TB through surface hydrogen bonding and ionic toughening and continuously release the biolubrication components into tissue fluid for rolling lubrication layers and liquid lubrication films. This long-lasting lubricating

SUBMITTER: Zhuang P 

PROVIDER: S-EPMC12547148 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature