Vaccination with a novel quadrivalent fusion protein protects chickens against necrotic enteritis lesions caused by Clostridium perfringens.

ABSTRACT: Necrotic enteritis (NE), caused by Clostridium perfringens, is a debilitating disease that results in significant production losses in the poultry industry. Traditionally, antibiotics have been used to control NE in flocks; however, due to concerns about the potential for selection of antibiotic resistance, antibiotic residues in meat, and restrictions on antibiotic use in some regions, alternative methods to control this disease are needed. In previous studies, proteins such as NetB, the key virulence factor, and alpha toxin have been used individually as subunit vaccines, but only partial protection was induced. It appears that a single subunit antigen is insufficient to produce high levels of protection. Here, an experimental vaccine, incorporating fragments from four antigens, was desi

SUBMITTER: Manohar MM 

PROVIDER: S-EPMC12547217 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature