Hematoma-inspired injectable composite hydrogels incorporating hybrid metal ion microspheres for accelerated bone regeneration.

ABSTRACT: Injectable hydrogels emerge as a particularly attractive candidate in bone tissue engineering, due to their minimally invasive administration and conformal filling for irregular bone defects. However, they still lack sufficient osteoinductive activities for effective bone repair. Herein, we engineer a hematoma-inspired injectable composite hydrogel consisting of polylactide microspheres encapsulated with magnesium oxide and strontium oxide and the alginate hydrogel crosslinked by slow release of Ca²⁺ for promoting bone regeneration in critical-sized bone defects. A complementary release of rapidly released Sr²⁺ and gradually released Mg²⁺ effectively promotes the proliferation, migration and osteogenic differentiation of bone marrow mesenchymal stem cells a

SUBMITTER: Cao F 

PROVIDER: S-EPMC12547220 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature