Integrating Gut Microbiome and Metabolome to Gain Insight into Metabolic Dysfunction-Associated Steatotic Liver Disease.

ABSTRACT:

Background and aims

Recent evidence has implicated the gut microbiome in the regulation of host metabolites and the pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD). However, the role of gut microbiome and its associated metabolites as regulators and/or modulators in MASLD remains understudied. We aimed to investigate the gut microbiome diversity and composition, its interaction with plasma metabolites, and MASLD risk using population-level data.

Methods

We combined 16S rRNA sequencing of stool samples with a wide range of plasma metabolites measured by the Metabolon HD4 platform, and MASLD diagnosed by abdominal ultrasound in the Rotterdam Study cohort at baseline, between 2012 and 2014. We assessed the relationship of gut microbiome and meta

SUBMITTER: Zhang X 

PROVIDER: S-EPMC12547235 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature