Plasma Ceramide C24:0/C16:0 Relates to Outcomes in Patients With Heart Failure With Preserved Ejection Fraction.

ABSTRACT:

Background

Ceramides are complex sphingolipids with pleiotropic effects. The ratio of specific ceramides (plasma C24:0/C16:0) is inversely related to incident heart failure (HF) and all-cause death in large, community-based cohorts without pre-existing HF. Whether plasma C24:0/C16:0 relates to outcomes in patients with HF with preserved ejection fraction (HFpEF) is unclear. We hypothesized plasma C24:0/C16:0 would be inversely related to, and independently predict, outcomes in HFpEF patients.

Objectives

To test our hypothesis, we used plasma samples, baseline, and outcomes data from the TOPCAT (Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist) trial. Findings were extended to a community-based cohort of HFpEF patients from the SHIP (Study

SUBMITTER: Peterson LR 

PROVIDER: S-EPMC12547264 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature