Tengchuan compound mixture ameliorates Mycoplasma Synoviae-induced synovitis: An integrated network pharmacology, metabolomics, and 16S rRNA sequencing study.

ABSTRACT: Mycoplasma synoviae (MS) is a prevalent pathogen in poultry farming, often causing infectious synovitis and arthritis in poultry, resulting in joint swelling, lameness, and growth retardation, thereby significantly impacting production efficiency. Tengchuan compound mixture (TCM), a traditional Chinese medicine formulation designed to against MS infection effectively, but its active components and mechanisms isn't elucidated. This study utilized liquid chromatography-mass spectrometry (LC-MS) to identify the active components in TCM and employed network pharmacology to predict key targets and pathways in against MS infection. A model of MS infection was established in specific-pathogen-free (SPF) chickens to assess the pharmacodynamic effects of TCM on parameters such as body weight, clini

SUBMITTER: Kan Q 

PROVIDER: S-EPMC12547265 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature