Assessing the neuroendocrine and psychological effects of acute everolimus administration in healthy male participants.

ABSTRACT: Previous experimental studies have shown that immunosuppressive mechanistic target of rapamycin inhibitors can induce neuropsychological changes, such as anxiety and depression, in healthy rodents. Furthermore, psychiatric conditions including anxiety have been reported in transplant patients and healthy subjects receiving the mechanistic target of rapamycin inhibitor everolimus. Thus, the present study aimed to further investigate the potentially dose-dependent neuroendocrine and psychological adverse side effects of acute everolimus intake in healthy male subjects. To this end, P70S6 kinase and Akt expression and phosphorylation in peripheral mononuclear blood cells as well as plasma and saliva cortisol, plasma noradrenaline and plasma dehydroepiandrosterone sulfate have been evaluated v

SUBMITTER: Jacquet L 

PROVIDER: S-EPMC12547271 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature