The Impact of Cirrhosis Severity and Spironolactone on Sex Hormone Levels in Men.

ABSTRACT:

Background and aims

Men with cirrhosis frequently experience endocrine dysfunction which is worsened with use of spironolactone for ascites. Both decreased testosterone and increased estrogen levels have been incriminated for these effects.

Methods

A cross-sectional study was conducted on 45 men with cirrhosis. A comprehensive clinical assessment of cirrhosis severity and sex hormone profile [total testosterone (TT), free testosterone (FT), total estrogen, estrone (E1), estradiol (E2) levels, and ratios] were performed. The relationship between cirrhosis severity and spironolactone therapy (ST) with hormone levels was assessed.

Results

Forty-five men with cirrhosis (age 31-76 years, mean 60.3 ± 8.6) were evaluated, including 17 on ST and 28 not on (no history of spiro

SUBMITTER: Akin Belli A 

PROVIDER: S-EPMC12547313 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature