Network Modeling of Biomarker Systems in Liver Steatosis and Fibrosis.

ABSTRACT: Metabolic dysfunction-associated fatty liver disease causes hepatic fat accumulation (steatosis) and fibrosis, which can be measured with ultrasound elastography imaging. The dependencies of elastography-derived hepatic steatosis and fibrosis measures with chronic inflammation, disease states, and physiological determinants of drug dosing (PDODD) were assessed. Liver elastography data for n = 5494 participants (50% female, 12-80 years) were obtained from the National Health and Nutrition Examination Survey. Controlled attenuation parameter (CAP) and median liver stiffness (LSM) elastography metrics were used to assess steatosis and fibrosis, and their associations with over 50 key organ systems, disease, and PDODD biomarkers were evaluated with statistical regression, ensemble, and Bayesia

SUBMITTER: Bhat AG 

PROVIDER: S-EPMC12547354 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature