Adding implantable cardioverter-defibrillator to cardiac resynchronization therapy in patients with non-ischemic cardiomyopathy: a systematic review and meta-analysis with focus on elderly subpopulation.

ABSTRACT:

Background

Cardiac resynchronization therapy (CRT) has been a major therapeutic advancement for patients with heart failure and electrical dyssynchrony. While CRT improves symptoms, reduces hospitalizations, and enhances survival, the role of implantable cardioverter-defibrillators (ICDs) alongside CRT in patients with non-ischemic cardiomyopathy (NICM) remains controversial. To evaluate and compare the outcomes of CRT with ICD (CRT-D) versus CRT with pacemaker-only (CRT-P) in individuals diagnosed with NICM, with a specific focus on the elderly.

Methods

A comprehensive search of PubMed, Embase, and the Cochrane Central Register of Controlled Trials was conducted in January 2024. Studies comparing CRT-D and CRT-P in patients with NICM were included, with subgroup analyses fo

SUBMITTER: Neto VD 

PROVIDER: S-EPMC12547413 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature