Shield microneedles loaded with biphasic-delivery liposomes modulate skin oxidation/immunity dual-axis for psoriasis therapy.

ABSTRACT: 5-Aminolevulinic acid-based photodynamic therapy (ALA-PDT) has emerged as a promising therapeutic strategy for psoriasis owing to its non-invasiveness and high selectivity. However, clinical translation is hindered by inadequate cutaneous permeability and the paradoxical interplay between pro-apoptotic effect and oxidative stress. Therefore, this study develops biphasic delivery liposome loaded with 5-ALA and ginsenoside Rg3, and designs hydrogel-backed shield microneedles (SMNs) inspired by shield tunneling principles to achieve efficient delivery. Flow cytometry analysis demonstrates that the biphasic delivery liposome harnesses Rg3 to activate the SOD/CAT antioxidant enzyme system, thereby scavenging excess reactive oxygen species (ROS) generated by 5-ALA-PDT. Incorporation of this lipo

SUBMITTER: Yang Q 

PROVIDER: S-EPMC12547502 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature