Pseudolaric acid B induces G2/M phase arrest in canine mammary tumor cells by targeting CDK1.

ABSTRACT:

Introduction

Current management of canine mammary tumors (CMTs) remains reliant on surgical resection and chemotherapy. However, these strategies are often limited by high recurrence rates and systemic toxicity. Addressing these limitations requires urgent development of safer and more effective therapeutics. Pseudolaric acid B (PAB), a bioactive compound extracted from the roots of the Pseudolarix kaempferi Gord., has garnered attention for its broad-spectrum antitumor activity and favorable pharmacokinetic profile, and it has shown promise in inhibiting the growth of a variety of tumors, including breast cancer. The aim of this study was to investigate the anticancer effects of PAB on canine mammary tumor U27 cells and its underlying mechanisms.

Methods and results

SUBMITTER: Chen M 

PROVIDER: S-EPMC12547503 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature