Integrated Multiomics Elucidates Glutathione Metabolic Regulation in a Marine Aromatic Probiotic Yeast <i>Meyerozyma guilliermondii</i> GXDK6 under Salt Stress.

ABSTRACT: High-salt environments impose significant oxidative stress on microorganisms by disrupting redox homeostasis, necessitating efficient adaptive mechanisms such as glutathione (GSH) metabolism. Meyerozyma guilliermondii GXDK6, a marine-derived multistress-tolerant probiotic yeast, exhibits robust salt tolerance; however, the molecular basis of its GSH-mediated regulatory networks under salt stress remains unexplored. In this study, a comprehensive multiomics approach, integrating whole-genome sequencing, transcriptomics, and proteomics profiling, along with targeted physiological assays, was employed to investigate GSH metabolic regulation under salt stress. Genome-wide analysis identified 55 genes involved in other amino acid metabolism, with transcriptomic and proteomic profiling re

SUBMITTER: Li Z 

PROVIDER: S-EPMC12547565 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature