Advanced Electrochemical C-C Bond Formation Using a Michael-Type Nozaki-Hiyama-Kishi (NHK) Reaction.

ABSTRACT: Herein focuses on using organometallic electrochemistry for the electrochemical allylation of dihydroxybenzenes and 4,4'-biphenol, employing a mechanism based on the Nozaki-Hiyama-Kishi (NHK) reaction. The NHK reaction, known for its nickel/chromium cross-coupling process, is applied to synthesize allylic alcohol adducts. A convergent paired-electrochemical mechanism is used, catalyzed by NiCl₂ in Bu₄NClO₄/DMF media, and optimized through a multiparameter Design of Experiments (DoE) approach. The study systematically evaluates reaction conditions, considering parameters such as electrode material and current density in an undivided electrochemical cell. DoE allows efficient screening, reducing the number of experiments while optimizing key factors affecting

SUBMITTER: Torabi S 

PROVIDER: S-EPMC12547569 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature