Trial Enrollment and Survival Disparities Among Patients With Advanced Epithelial Ovarian Carcinoma.

ABSTRACT:

Importance

Racial differences in epithelial ovarian cancer (EOC) might result in survival inequities.

Objective

To evaluate enrollment and outcomes by race in Gynecologic Oncology Group (GOG) randomized clinical trials (RCTs) among patients with EOC.

Design, setting, and participants

This cohort study used ancillary data from completed RCTs using protocols GOG-111, GOG-114, GOG-158, and GOG-172 under a data sharing agreement with National Research Group Oncology. Patients with stage III or IV EOC in first-line RCT protocol GOG-111 had suboptimally resected disease, whereas those in GOG-114, GOG-158, or GOG-172 had optimally resected disease. RCTs were conducted and published between 1996 and 2006, and data for this study were analyzed in August 2024.

Exposure

R

SUBMITTER: Johnson CR 

PROVIDER: S-EPMC12547579 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature