Freeze-Dried Chitosan Scaffolds Containing Grape Seed Oil for Wound Healing Applications.

ABSTRACT: Wound healing is the ultimate goal in skin repair and tissue engineering. Skin is highly susceptible to injuries, with a mortality rate in chronic wounds comparable to cancers, thus imposing a high cost ($126.8bi/USA) to health care systems. Chronic wound regeneration stagnates in the inflammatory phase, progressing after its control. Porous biomaterials with a tunable degradation that control bleeding and exudate and maintain a moist environment could improve skin repair. Chitosan is biocompatible, biodegradable, antimicrobial, and hemostatic. Vitis vinifera (grape) seed oil (grape seed oil (GSO)) has a high content of unsaturated fatty acids with antioxidant and anti-inflammatory activity. In this study, 0.3% and 0.6% (v/v) GSO were incorporated into chitosan without cross-linker

SUBMITTER: Dos Santos EF 

PROVIDER: S-EPMC12547589 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature