Carboxymethyl Ethylcellulose Acts as a Solid Dispersion Carrier with a Remarkably Higher Improvement Effect on Dissolution-Permeation of Itraconazole.

ABSTRACT: This study aimed to investigate solid dispersion formulations of itraconazole (ITZ) by using carboxymethyl ethylcellulose (CMEC) as an enteric cellulose derivative to improve stability, dissolution, and permeation profiles. Polyvinylpyrrolidone covinyl acetate (PVPVA) and hydroxypropyl methylcellulose acetate succinate (HPMCAS) were used as traditional carriers. Ball-milling successfully induced the formation of solid dispersions of ITZ with the used polymers, resulting in single-glass transition temperatures. The infrared spectra suggested the formation of hydrogen bonding between ITZ and each polymer. Water sorption of CMEC was comparable to that of HPMCAS, which was significantly lower than that of PVPVA, enabling the maintenance of the amorphous state of the solid dispersion under 40 °

SUBMITTER: Tanaka H 

PROVIDER: S-EPMC12547606 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature