Computational Evaluation of Azinane-Amide-Coupled Triazoles Enabled by an Alkali Metal Reagent as Anti-Enzymatic Agents.

ABSTRACT: A new electrophile was synthesized and merged with 1,2,4-triazole and piperidine to avail the aimed library of compounds, 10a _i‑v and 10b _i‑v . Various 4-(substituted)-benzenesulfonyl chlorides (1 _i‑v ) were treated with ethyl piperidin-4-carboxylate (2a) and ethyl piperidin-3-carboxylate (2b) to acquire 3a _i‑v and 3b _i‑v esters bearing a sulfamoyl moiety. These esters were converted to different 1,2,4-triazoles 6a _i‑v and 6b _i‑v through the formation of carbohydrazides and thiosemicarbazides as intermediates. A new electrophile, compound 9, was synthesized by reaction of bromoacetyl bromide (7

SUBMITTER: Munir Z 

PROVIDER: S-EPMC12547750 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature