Age-related Eye Disease Studies Supplements and Genetic Risk Score Are Crucial Determinants of Intestinal Microbial Alterations in Advanced Age-Related Macular Degeneration.

ABSTRACT:

Objective

Determine whether an intestinal microbial signature is associated with advanced age-related macular degeneration (AMD); investigate the relationship between the microbiota and AMD genetic risk, intestinal immunoglobulin-A (IgA), and Age-Related Eye Disease Studies (AREDS) supplementation.

Design

Case-control study.

Methods

Fecal 16S rRNA sequencing, DESeq2 differential abundance, and IgA-sequencing.

Subjects

Advanced AMD and age-similar non-AMD control subjects.

Main outcome measures

Differential abundance plots using DESeq2, α and β diversity, and impact of AREDS supplementation and genetic risk on AMD microbiota.

Results

In 85 advanced AMD compared with 49 healthy control subjects' intestinal microbiota, exploratory partial least-squar

SUBMITTER: Dadgar N 

PROVIDER: S-EPMC12547908 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature