Mild Dilatation of the Main Pancreatic Duct Is a Risk Factor for Progression to Pancreatic Cancer in High-Risk Individuals.

ABSTRACT:

Background and aims

Mild dilatation of the main pancreatic duct (MPD) can be an early indicator of an obstructing mass, but its clinical significance in asymptomatic high-risk individuals (HRIs) undergoing surveillance has not been defined. We determined the prevalence and incidence of MPD dilation in HRI and assessed its association with neoplastic progression (to high-grade dysplasia or pancreatic ductal adenocarcinoma (PDAC)) in HRI.

Methods

We analyzed prospectively collected data from HRIs enrolled in the Cancer of Pancreas Screening cohort studies. We determined the risk of neoplastic progression associated with MPD dilation (defined as ≥4, ≥3, ≥2 mm diameter, in the head, body, tail, respectively) using Cox regression and time-varying covariate analysis. We estimated

SUBMITTER: Diwan EA 

PROVIDER: S-EPMC12547912 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature