Effect of interleukin-17A on anti-ANT antibodies as well as cytokines in viral myocarditis mice.

ABSTRACT:

Objective

To observe the effect of interleukin-17A (IL-17A) on serum anti-mitochondrial endosomal ADP/ATP carrier autoantibody (anti-ANT antibody) levels and cytokines in viral myocarditis (VMC) mice.

Methods

Male wild-type (WT) and IL-17A knockout (IL-17A^-/-) BALB/c mice were intraperitoneally injected with coxsackievirus B3 (CVB3) to establish a VMC model (VMC-WT and VMC-IL-17A^-/-), while WT BALB/c mice were injected with PBS intraperitoneally to establish a normal control group (WT group). After 14 days, myocardial tissues were taken to calculate heart mass, and paraffin sections were prepared and stained with HE staining to observe the pathological changes and calculate the pathological score of myocardial tissues. Flow cytometry was used to detect

SUBMITTER: Li W 

PROVIDER: S-EPMC12547928 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature