Passivation-Engineered Zinc Peroxide Nanoparticles as Th1-Biased Adjuvant for Antitumor Immunity.

ABSTRACT: The efficacy of cancer vaccines depends significantly on adjuvants that can stimulate robust Th1 immune responses. However, conventional inorganic adjuvants like Alum generally elicit Th2-biased immune response. Despite recent efforts in developing organic adjuvants to mimic bacterial or viral infections for generating Th1 immunity, excessive inflammation remains a major concern. Herein, a new class of Th1-biased adjuvant is reported via passivation engineering of zinc peroxide nanoparticles (p-ZPNs) for potentiating the immunogenicity of cancer vaccines. p-ZPNs show improved biocompatibility compared to unpassivated ZPNs due to retarded zinc ion release and hydrogen peroxide production, as well as efficient cellular uptake, endosome escape, dendritic cell maturation and antigen cross pres

SUBMITTER: Luo J 

PROVIDER: S-EPMC12548014 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature