CCDC89 is required for optimal sperm motility and male fertility in mammals.

ABSTRACT:

Study question

What is the role of coiled-coil domain-containing protein 89 (CCDC89) in mammalian male fertility?

Summary answer

The presence of CCDC89 is required for normal sperm motility and therefore optimal male fertility in mice, while CCDC89 variants affected spermatogenesis in both mice and humans.

What is known already

Coiled-coiled domain-containing proteins play a variety of roles in biological processes, including cell division, the production of motile sperm, and the regulation of their motility.

Study design, size, duration

DNA from infertile men with azoospermia was sequenced to identify genetic variants as per the Genetics of Male Infertility Initiative (GEMINI) study. Genetic variants were identified in CCDC89 in three men, by whole exome seque

SUBMITTER: O'Bryan MK 

PROVIDER: S-EPMC12548035 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature