Durability Testing With Calcification of Surgical Aortic Valves and Transcatheter Heart Valves: An In Vitro Study.

ABSTRACT:

Objectives

Structural valve deterioration, mainly caused by calcification, is the Achilles heel of the bioprosthetic heart valves. While clinical long-term experience of surgical aortic valve (SAV) bioprostheses exists, transcatheter heart valve (THV) requires further investigations into biological degeneration. Therefore, this in vitro study aimed to analyse the calcification pattern of different SAV and THV models under standardized conditions.

Methods

SAVs (Perimount Magna Ease, Perimount, Mosaic Ultra and Hancock II) and THVs (Evolut PRO and SAPIEN XT) models were calcified with a calcification buffer (pH = 7.4 and CaCl2 = 1.5 mM) circulating at 37°C over 157.684 million cycles in a Hi-Cycle-tester to simulate 5 patient-years. Hydrodynamic performance (mean pressure grad

SUBMITTER: Sadat N 

PROVIDER: S-EPMC12548042 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature