The effect of preexisting antibodies from Tdap vaccination during pregnancy on infant antibody responses to the pertussis-containing vaccines.

ABSTRACT: Tetanus-diphtheria-acellular pertussis (Tdap) vaccination during pregnancy protects newborns from pertussis in the early months of life. Previous research indicated that Tdap vaccination during pregnancy may blunt Bordetella pertussis (B. pertussis)-specific antibody responses in infants following acellular (aP) and whole cell pertussis (wP) vaccination. However, the effect of preexisting antibodies on infants' responses to diphtheria toxoid (DT), tetanus toxoid (TT) and B. pertussis antigens is less well-understood. This study aims to quantify the effect of preexisting anti-DT, anti-TT, and B. pertussis-specific antibody levels from Tdap vaccination during pregnancy on infants' post-primary and post-booster responses to aP- and wP-containing vaccines. This retr

SUBMITTER: Sereeyothin C 

PROVIDER: S-EPMC12548071 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature