Assessing the Relationship between Foveal Cone Density, Outer Nuclear Layer Thickness and Foveal Morphology.

ABSTRACT:

Purpose

To assess the relationship between foveal cone topography, foveal outer nuclear layer (ONL) thickness, foveal morphology, and foveal avascular zone (FAZ) area in individuals with normal vision.

Design

Retrospective cross-sectional study.

Participants

A total of 68 participants with normal vision were included (49 female; 19 male).

Methods

Directional OCT images were used to derive ONL thickness measurements. Images of the foveal cone mosaic were obtained using adaptive optics scanning light ophthalmoscopy, from which peak cone density (PCD) was measured. Foveal avascular zone area and foveal pit morphology were estimated using OCT angiography images and OCT macular thickness maps, respectively.

Main outcome measures

Foveal cone density metrics, f

SUBMITTER: Zacharias S 

PROVIDER: S-EPMC12548097 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature