OCT-Derived Quantitative Measurement of Extent of Vascularization ("Zone") in Retinopathy of Prematurity.

ABSTRACT:

Purpose

To provide a quantitative approach to the measurement of zone in retinopathy of prematurity (ROP) using ultra-widefield OCT (UWF-OCT).

Design

Diagnostic accuracy study.

Subjects

Infants undergoing ROP screening at Oregon Health Science University between June 2023 and October 2024, whose parents consented for research imaging.

Methods

An investigational UWF-OCT captured scans from the first week of examination in which stage 1 or worse disease was noted on en face imaging in zone I, posterior zone II, or zone II, and image quality was adequate for quantitative analysis. A U-Net automatedly segmented B-scans to isolate the retina and choroid. En face images and retinal depth maps were used to manually identify the position of the optic nerve, fovea, and

SUBMITTER: Sutter DA 

PROVIDER: S-EPMC12548099 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature