Comparison of the safety and efficacy of moderately hypofractionated and conventionally fractionated radiotherapy for localized prostate cancer: evidence from 9074 men in 13 randomized clinical trials.

ABSTRACT:

Objectives

While moderately hypofractionated radiotherapy (HFRT) has been recommended as the standard regimen in localized prostate cancer (LPCa) based on non-inferiority trials compared to conventionally fractionated radiotherapy(CFRT), the conclusions on its efficacy and toxicity have not been consistent among all trials. This study aims to systematically compare the efficacy and safety of HFRT with CFRT for LPCa based on the present randomized controlled trials. The longest follow-up data from all the trials were adopted.

Methods and materials

This research followed the steps outlined in the PRISMA statement for meta-analyses and systematic reviews. This study presents a meta-analysis of phase III trials comparing CFRT with HFRT for LPCa. The included trials reported rela

SUBMITTER: Chen H 

PROVIDER: S-EPMC12548115 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature