Single atom-bridged Au nanozymes boost glucose oxidase-like activity in acidic media.

ABSTRACT: Although Au nanozymes hold great promise as glucose oxidase (GOx) mimics, their catalytic activity and pH dependence remain significant challenges. Herein, we synthesize Fe single atom bridged Au nanozymes (Au_NPs/FeNC) with dual catalytic sites, achieving a 3.7-fold enhancement in GOx-like activity under acidic media compared to Au_NPs/NC. Experimental and theoretical analyses reveal that charge transfer from Au to Fe single atom facilitates O₂ adsorption at Fe sites, synergistically boosting glucose oxidation. Unlike previously reported Au-H intermediates formed under alkaline conditions, in situ monitoring identifies the formation of Au-Fe-OO intermediates in Au_NPs/FeNC, which facilitate the dehydrogenation of glucose and enhance the cata

SUBMITTER: Luo X 

PROVIDER: S-EPMC12548119 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature