HuoXue QianYang QuTan recipe attenuates myocardial hypertrophy in obese hypertensive rats by regulating MPC1/MCT4 mediated pyruvate-lactate metabolic axis.

ABSTRACT:

Background

HuoXue QianYang QuTan Recipe (HQQR) is an effective prescription for the clinical management of myocardial hypertrophy in patients with obesity-related hypertension (OBH). In previous studies, HQQR showed the pharmacological properties of mitochondrial protection, anti-inflammatory, and anti-oxidant in OBH rats, which were closely related to its cardioprotective effects. This study is designed to further explore the molecular mechanisms by which HQQR attenuates myocardial hypertrophy in OBH rats.

Methods

High-fat diet-fed SHR were gavaged with HQQR (5 ml/kg or 10 ml/kg, 3.87 g/ml of original drug) or Valsartan (10 ml/kg, 3 mg/ml of original drug) for 10 weeks. In vitro, the H9C2 cells were stimulated with angiotensin-II (Ang-II) and (or) free fatty acid (FFA) in t

SUBMITTER: Wang J 

PROVIDER: S-EPMC12548125 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature